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Symbol
Name
ID

Cyld
CYLD lysine 63 deubiquitinase
MGI:1921506

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

increased susceptibility to induced colitis

thymus hyperplasia

enlarged spleen

abnormal B cell differentiation

abnormal class switch recombination

decreased immature B cell number

increased pro-B cell number

increased double-positive T cell number

decreased B-1 B cell number

increased follicular B cell number

increased marginal zone B cell number

increased B cell number

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

abnormal B cell morphology

abnormal mature B cell morphology

abnormal spleen morphology

abnormal spleen marginal zone morphology

abnormal B cell physiology

increased IgA level

increased IgG1 level

increased IgG2a level

increased IgG2b level

decreased IgG3 level

decreased IgM level

abnormal Peyer's patch germinal center morphology

enlarged Peyer's patches

enlarged lymph nodes

abnormal humoral immune response

abnormal inflammatory response

decreased susceptibility to bacterial infection

decreased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Cyld^tm1.1Awai/Cyld^tm1.1Awai

Cyld^tm1Jdgl/Cyld^tm1Jdgl

Cyld^tm1Lex/Cyld^tm1Lex

*

Cyld^tm1Ref/Cyld^tm1Ref

*

Cyld^tm1Scs/Cyld^tm1Scs

Cyld^tm1Awai/Cyld^tm1Awai
Tg(CD19-cre/ERT2)1Cgn/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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